Abstract

ANTI-CANDIDIASIS ACTIVITY OF THE ORANGE JASMINE (MURRAYA PANICULATA [L.] JACK.) AND SYZYGIUM POLYANTHUM [WIGHT.] WALP. LEAVES ETHANOL EXTRACT

Sri Agung Fitri Kusuma*, Irma Erika H., Danni Ramdhani, Nur Yuliasih, Evi Purnamasari

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Abstract

Objective: The present study investigated the antifungal properties of different extract of the Orange jasmine and Syzygium polyanthum leaf extract against Candida albicans. Methods: Total extract of both leaves were prepared using a maceration method in 70% ethanol solution. The screening of phytochemicals was done using a conventional procedure. The agar diffusion technique was used to evaluate antifungal activity. In order to identify the minimum fungicidal concentration (MFC), the minimum inhibition concentration (MIC) test was also conducted using a macrodilution method and followed by subculturing the overnight result on the surface of agar medium. Results: According to the findings, the growth of C. albicans was inhibited by ethanol extract of O. jasmine leaves with MIC/MFC values ranging from 0.3125 to 0.625 % w/v. This value was higher than that of S. polyanthum with the MIC/MFC from 0.1562 to 0.3125 %w/v. Conclusion: Those MIC/MFC values demonstrated the effectivity of S. polyanthum was better than O. jasmine to be anticandidiasis natural agent.

Keywords: Orange jasmine, Syzygium polyanthum, Candida albicans, MIC, MFC.