Abstract

A REVIEW ON ADVERSE DRUG REACTIONS ASSOCIATED WITH THE USE OF REMDESIVIR IN THE TREATMENT OF COVID-19

Sumaiya Saleem*, Indurthi Bharathi, Thati Sravani, Devagupthapu Kunthitha Devi, Purushothama Reddy K. and Kantamaneni Padmalatha

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Abstract

According to WHO, Coronavirus disease (COVID-19) is a highly infectious disease caused by the novel coronavirus (SARS-CoV-2). SARS-CoV-2 is a single-stranded RNA virus that mainly affects the respiratory and gastrointestinal system. Remdesivir is an antiviral drug used in the treatment of COVID- 19 after it showed its potency in the treatment of the Ebola virus disease. Though remdesivir is an effective drug, it shows adverse drug reactions in various organ systems. According to the literature search, the use of remdesivir corresponds with increased reporting of kidney disorders, hepatic disorders, and cardiac events. There was no significant evidence to associate remdesivir with neuropsychological disorders. The study concludes that further confirmatory studies are needed to verify a causal association between remdesivir and the ADRs observed.

Keywords: COVID- 19, Adverse drug reactions, Remdesivir, Kidney disorders, Hepatic disorders, Cardiac events, and Neuropsychological disorders.