Abstract

FORMULATION AND EVALUATION OF POLYHERBAL ANTI-ACNE NANOGEL

Remya S. B.*, Akshara A. R., Neethu Mol B., Parvathy S., Pooja P., Sreethu R. Nair

.

Abstract

Acne is the most common skin problem that can occur due to a bacterial infection. Pimples, acne, sunburn marks and pigmentation are issues that can affects every individual at least once during their life time. Consumers have began to search for a product that can cure the skin issue and grant them with a good and healthy skin, such as antiacne cream or anti acne gel. The gel based, oil free formulations are always preferred. Nevertheless, most of the anti-acne gels available on the market contain lots of chemicals that may have some kinds of side effects on consumers. The present study was conducted to formulate and evaluate the polyherbal anti-acne nanogel containing extracts of orange, moong dal, sheath scale of coconut, honey and tea tree oil in an aqueous-based carbopol gel system. Nanogels were characterized by organoleptic, pH, viscosity, spreadability, antibacterial activity, and stability studies. The antibacterial activity of the nanogel formulation in different concentrations was investigated using Staphylococcus aureus through agar well diffusion method. The F2 formulation produces excellent antibacterial activity and sufficient gelling consistency. It was concluded that the present research might hopefully bring advancement in the treatment of acne using herbs as well as developing polyherbal formulations for safe and effective management of disease.

Keywords: orange, moong dal, sheath scale of coconut, honey, tea tree oil.