Abstract

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF SPECTROSCOPIC ESTIMATION OF IBUPROFEN USING HYDROTROPIC SOLUBILIZATION TECHNIQUE

Muskan Panchal*, Umesh K. Atneria and Dr. Dharmendra Solanki

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Abstract

The objective of this study was to improve the solubility of ibuprofen followed by the development and validation of analytical method for the determination of drugs in bulk, in dosage forms for quality control, bioavailability and pharmacokinetic study etc. The use of hydrotropic agents such as sodium benzoate and sodium citrate has significantly increased the solubility of ibuprofen in aqueous solutions, allowing for easy and accurate measurement of its spectroscopic properties. The developed method showed good linearity over the concentration range of 10-50 μg/mL with correlation coefficient (R2) of 0.998. The percentage recovery of ibuprofen was found to be near to 100% for both hydrotropic agents. The method was validated as per the ICH guidelines for various parameters including precision, accuracy, specificity, and robustness. The results obtained from the validation studies were found to be within acceptable limits, indicating that the method is reliable and accurate for the estimation of ibuprofen. In conclusion, the developed method using hydrotropic solubilization technique provides a simple, rapid, and cost-effective way for the spectroscopic estimation of ibuprofen in pharmaceutical formulations. The method can be easily implemented in routine quality control laboratories for the analysis of ibuprofen with high accuracy and precision.

Keywords: Ibuprofen, Hydrotropy, Validation, Analytical Method, Estimation.