Abstract

INVESTIGATION OF NEUROPROTECTIVE POTENTIAL OF METHANOLIC EXTRACT OF T. INDICA BARK AGAINST MPTP INDUCED PARKINSONISM

Dona Sarkar*, Ananya Bhattacharjee, Manodeep Chakraborty and Nihar Ranjan Bhuyan

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Abstract

The four cardinal signs of Parkinson disease are stiffness, resting tremor, slowness (bradykinesia), and loss in movement (hypokinesia). In the past few decades, a number of traditional Parkinson's treatments were found, although they occasionally cause toxicity and have adverse effects. Because they have fewer negative effects, plant products with active phytochemicals are used for a range of medicinal applications. In this present study in vivo antiparkinson activity of the methanolic extract of T. indica bark has been evolved by using animal experimental models. Parkinson disease is induced by administration of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (20 mg/kg/day, i.p) for 14 consecutive days. The symptoms of PD such as akinesia and rigidity were evaluated. The effect was evaluated by assessing various behavioral parameters (catalepsy, grip strength and locomotor activity). The methanolic extract of T. indica bark at the doses of 100 mg/kg and 200 mg/kg have shown significant (p

Keywords: Antiparkinson activity, T. indica, 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP), Levodopa-carbidopa combination.