Abstract

FORMULATION AND EVALUATION OF FLOATING DRUG DELIVERY OF FEXOFENADINE HCL

Voleti Vijaya Kumar*, Y. Ismail, M. Nandhini, P. Shanmugapandiyan and Kommu Pradeep

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Abstract

The main objective of present research is to formulate a sustained release floating drug delivery of fexofenadine HCl by direct compression method. Nine different formulations of fexofenadine HCl floating tablets were developed with a gas generating agent NaHCO3 and in combination with various polymers like HPMC K4M, HPMC K100M, Tamarindus seed powder in different ratios. Drug Excipient compatibility study was confirmed by FTIR. The developed formulations were evaluated for various physicochemical parameters like swelling index, weight variation, friability, hardness, floating lag time and in‐vitro drug release, Formulation F9 was considered as an optimized formulation on basis of acceptable tablet properties and in vitro drug and was found to follow Higuchi release kinetics and zero order.

Keywords: Fexofenadine HCl, Gastroretentive drug delivery systems, NaHCO3, floating tablets, HPMC K4M.