Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF ANTIMICROBIAL DRUG LOADED MICROSPONGES FOR TOPICAL DRUG DELIVERY

Farsana T.*, Geetha V. S., Jumana K. K. and Mubashira N. P.

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Abstract

Acne vulgaris is a skin condition that occurs when hair follicles plug with oil and dead skin cells. It causes redness, whiteheads, blackheads or pimples. The infection is caused by Propionibacterium acne and staphylococcus aureus. The primary bacteria that cause this disease are Propionibacterium acne. azithromycin is an antibacterial drug effective against these microorganisms. Negative aspects associated with oral systemic antimicrobial therapy for acne include its limited success rate, toxicity, contraindications, drug interactions, high cost of medication and increased microbial resistance. But topical therapy does not lead to systemic side effects or drug interactions. Therefore, the aim of the present study was to produce ethyl cellulose microsponges containing azithromycin which were able to control the release of azithromycin to the skin.

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