Abstract

A REVIEW ON STOMACH SPECIFIC FLOATING IN-SITU GEL

Rushikesh Jadhav*, Pratik Jadhav, Sheetal Gondkar, Rishikesh Bachhav

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Abstract

The development of floating-dependent technology has given people the opportunity to overcome a variety of difficulties, including physiological issues that impact the body's capacity to absorb drugs, such as unstable stomach emptying and low residency times. Drug formulation as a controlled release, gastro-retentive dosage form that could remain in the stomach for several hours would greatly extend the gastric residence duration, improve bioavailability, decrease drug waste, and improve the solubility of the medication. The oral in situ gel is a unique dosage form that may be designed as a floating system in terms of floating technology. It starts out as a liquid but changes into a floating gel as it comes into touch with the stomach's contents. Gel transitions arise via a variety of causes, including chemical reactions, biomaterials physical changes, and physiological activation. To get over the issues of short gastric residence time and rapid drug release, these appliances have been used to locally or systemically distribute various drugs in the stomach. The floating oral in-situ gel formulation, its mechanisms of action, formulation techniques, in vitro and in vivo evaluation, and research on a variety of medications and polymers conducted by various researchers are all covered in detail in this review. It also provides a brief overview of floating technology in general.

Keywords: Floating drug delivery systems, In situ gel, Stomach, Swelling, Diffusion etc.