Abstract

NANOSUSPENSION: AN PROMOTED DRUG DELIVERY SYSTEM

Roshan K. Aher*, Shubham C. Mulmule, Tanvirahmad J. Shaik and Rajendra D. Wagh

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Abstract

Regardless of the route of administration, solubility is a key factor in a drug's effectiveness. Development attempts have been abandoned in large numbers because many recently identified medications are poorly bioavailable and water insoluble. These so-called "Brickellia" candidates can now be administered because they have been transformed into a nanosuspension. The use of nanosuspension technology has improved the water solubility and bioavailability of pharmaceuticals. Utilising nanosuspension technology can improve drug stability and bioavailability. All drugs that are insoluble in water can be made into nanosuspensions, which is a simple procedure. Nanosuspensions are made using the wet mill, high pressure homogenizer, melt emulsification method, emulsion solvent evaporation, and super critical fluid procedures. Nanosuspension can be made using stabilisers, organic solvents, and other additives including buffers, salts, polyols, osmogent, and cryoprotectants. Nanosuspensions can be administered orally, parenterally, pulmonaryly, or intravenously. Targeted medication distribution is also made possible by incorporating nanosuspensions into ocular inserts and mucoadhesive hydrogels.

Keywords: Saturation, dissolution, nanosuspension, solubility, and solubility improvement.