Abstract

RECENT ADVANCE IN FLOATING DRUG DELIVERY SYSTEM: AN OVERVIEW

Dixit K. Prajapati*, Dr. Mukesh S. Patel, Dr. Mukesh R. Patel

Abstract

Oral controlled release drug delivery systems are programmed to deliver the drug in predictable time frame that will increase the efficacy, minimize the adverse effects and increase the bioavailability of drugs. This triggered an increased interest towards formulation of novel delivery systems which retained in the stomach for prolonged and predictable period of time. Oral drug delivery of nearly half of the drugs gets thwarted owing to the high lipophilic nature. Bioavailability of these drugs being function of their aqueous solubility and dissolution tends to exhibit low magnitude and high intra and inter subject variability. Many drugs have a short biological half life and thus have invents potential in ameliorating GI absorption. Recent technological and scientific research has been devoted to the development of rate controlled drug delivery systems to overcome physiological adversities such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). This review discusses overall approaches of gastro retentive drug delivery systems and limelight on floating drug delivery its formulation development, factors, and discusses various in-vitro and in-vivo evaluation parameters. The present review addresses briefly about the floating drug delivery systems.

Keywords: Floating drug delivery system, Gastro Retentive system, Evaluation in vivo and in vitro, Buoyant delivery system.