Abstract

THE ROLE OF CYTOCHROME P450 IN DRUG METABOLISM

Ayodhya B. Khedkar*, Shrikant P. Gavhale., Shubhangi D. Narsale

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Abstract

Cytochrome P450 is a family of isozymes responsible for the biotransformation of several drugs. Drug metabolism via the cytochrome P450 system has emerged as an important determinant in the occurrence of several drug interactions that can result in drug toxicities, reduced pharmacological effect, and adverse drug reactions. Recognizing whether the drugs involved act as enzyme substrates, inducers, or inhibitors can prevent clinically significant interactions from occurring. Avoiding coadministration or anticipating potential problems and adjusting a patient's drug regimen early in the course of therapy can provide optimal response with minimal adverse effects.

Keywords: Hemeprotein, substrate, inhibitors, xenobiotics, allosteric site, Prosthetic site, ligand, isoforms.