Abstract

A REVIEW ON DUAL RELEASE ORAL RECONSTITUTABLE SUSPENSION

Shraddha R Damor*, Sahilhusen I. Jethara, Dr. Mukesh S. Patel,
Dr. Mukesh R. Patel 

Abstract

The oral route of administration is the most important route of administering drugs for systemic effects. Reconstitutable suspensions necessitate water to prior for mixing. Sustained release (SR) suspensions aimed at controlling the rate of release by maintaining desire drug levels in the blood for long duration of time. The most popular dosage forms beings tablets and capsules, but one major drawback of the dosage forms however is the difficulty to swallow for children and the patients who have swallowing disorder. The scenario of drug delivery is rapidly changing; conventional dosage forms are being replaced by new DDS. An oral dual sustained release suspension has been one of the most favorable dosage forms for pediatric and geriatric patients or patients unable to tolerate solid dosage forms. The multipurticulate dosage forms like pellets are being formulated as liquid suspensions that are the ideal dosage form for pediatrics and geriatric patients due to their flexibility in measurement of dose and ease of swallowing, pleasant taste and attractive coloring and flavoring agent. More therapeutic advantages are as high patient compliance, reduction in side effects and improvement of bioavailability could be expected by incorporating a function of SR drug into the suspension. The dual-release pharmaceutical suspensions upon reconstitution remains stable till its consumption and also provide a dualrelease of the active agent.

Keywords: Dual release, Sustained release, pellets, reconstitutable suspension, Drug delivery, Oral route