Abstract

FORMULATION AND EVALUATION OF ANTIMICROBIAL TRANSDERMAL PATCH BY USING AZADIRACHTA INDICA AND CURCUMIN

Saurabh Punia*, Kumari Preeti, Ruchi Yadav and Mithilesh Chaurasiya

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Abstract

Synthetic medications, which are presently offered as transdermal patches, are a mainstay of treatment for numerous disorders. Traditional medicine is a centuries-old practise that is once again gaining popularity. Therefore, herbal products can be applied as transdermal patches to treat a variety of illnesses. Neem leaves can be utilised to reduce airborne bacterial pollution since they have antibacterial qualities. Neem is a traditionally used plant known as Azadirachta indica. A transdermal patch comprising Azadirachta indica and curcumin was developed, extracted, and evaluated in the current investigation. The four transdermal patches in total were createdby using the solvent casting process and assessed for physicochemical traits such as weight fluctuation, thickness, drug content homogeneity, folding durability, invitro diffusion, ex-vivo permeation investigations, and anti-microbial screening test. There was no incompatibility between the medication and the polymer, according to infrared spectroscopy. The percentage of medication release at the end of 21 hours ranged from 65.2% to 92.06% according to in-vitro diffusion experiments on transdermal neem patches. Release kinetics information demonstrated that all formulations used a non-Fickian diffusion mechanism and zero order kinetics. The results of the anti-microbial screening investigation against Bacillus subtilis and Pseudomonas aeruginosa indicated good anti-microbial efficacy, and the zone of inhibition (ZOI) was compared to Penicillin and Streptomycin, two common antibiotics.

Keywords: Azadirachta indica, Curcumin, in-vitro, DMSO, Transdermal patch.