Abstract

DESIGN, SYNTHESIS & MOLECULAR PROPERTIES PREDICTION OF NOVEL HETEROCYCLE DERIVATIVES BY INSILICO METHODS

Palupanuri Naveena*, Dr. G. Tulja Rani, K. Malathi Lavanya, K. Ramya, M. Preethi and Syed Sarfaraz

.

Abstract

Isatin derivatives belongs to heterocyclic compound. Isatins derivatives are synthetically important substrates which can be further used for the synthesis of large variety of heterocyclic compounds. Isatins posses numerous biological properties like anti-inflammatory, anti depressant, anticonvulsant, antihelmintic, antimicrobial, anti allergic and the present study outlines the synthesis, molecular properties prediction, docking studies of noval isatin derivatives. Isatin consist of indole nucleus also known as oxindole and endogenous poly functional heterocyclic compound. So here we synthesized various substituted isatin derivatives by treating with monothiocarbohydrazones and benzene sulphonyl chlorides.

Keywords: Isatin, monothiocarbohydrazones, benzene sulphonyl chlorides, antibacterial, docking.