Abstract

NIOSOMES: THE VERSATILE VESICULAR DELIVERY SYSTEMS-A SYSTEMATIC REVIEW

Yadla Bhuvana Lakshmi*, Pasupuleti Divya and Hyma P.

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Abstract

Niosomes refer to vesicles composed of non-ionic surfactant-based multilamellar or unilamellar structures, where a membrane formed by surfactant macromolecules organizes as a bilayer to encapsulate an aqueous solute solution. The term "Niosomes" originated from "nonionic surfactants" as these vesicles consist of a bilayer of non-ionic surface-active substances. These Niosomes represent a distinctive drug delivery technology that safely encapsulates medications within vesicles. In contrast to hazardous and unsuitable Ionic drug carriers, Niosomal drug carriers pose lower risks. Moreover, Niosomes exhibit remarkable stability and do not necessitate specific handling or storage conditions. As a drug carrier, Niosomes show promising potential in reducing medication side effects and enhancing therapeutic insolubility, instability, limited bioavailability, and rapid degradation. This review article delves into the advantages, preparation methods, evaluation, and medicinal applications of Niosomes.

Keywords: Niosomes, Compositions, Preparation methods, vesicles, Evaluation, Applications.