Abstract

PROTEIN KINASE: STRUCTURE, FUNCTION, AND ITS ACTION ON VARIOUS DISEASES.

Greeshma Sebastian, Jaishna Jayachandran Nambiar, Jazeela Abdulkhader, Ayisha Ummer, Shifla Kareem, Minil Mukundan, Aiswarya Lakshmi Appil Gopalakrishnan and Siju Ellickal Narayanan*

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Abstract

Protein kinase is a very important drug target that helps in the regulation of cells. Protein kinase C-related kinases are of three types of PRK, PRK 1, PRK 2, and PRK 3, PRK 3 was first detected in metastatic cancers and later was found in low levels in all tissues. The specificity of phosphorylation by protein kinase is important for the integrity of signal transduction. Protein kinase is responsible for communication that occurs between one cell or a part of the cell to another called signal transduction. Different kinase inhibitors include Type I, II, III, and IV. AMP-activated protein kinase combines various regulatory signals. Receptor tyrosine kinases regulate the information transferred through signal transduction pathways. Tyrosine kinases have become important targets for drug discovery due to their involvement in the development and progression of tumors. Protein kinases have a role in several biological processes, including differentiation, cell survival, and cell cycle regulation. The largest protein family the human genome's gene coding represents is the G protein-coupled receptor (GPCR) family. Nuclear receptors (NR) are those that are located inside the nucleus and the molecules should enter into the cell to bind to the receptor. The activation of central MAPKs by kinase cascades activates transcription factors that cause inflammation in Asthma. The suppression of DNA-protein kinase can increase cellular sensitivity to IR and DNAdamaging substances in cancer therapy. The specific CK2 inhibitor CX-4945 has repeatedly been demonstrated to limit the DNA repair response to anticancer medications.

Keywords: Protein kinase, Signalling, Receptor, Tyrosine Kinase, Inhibitors.