Abstract

EVALUATION OF ANTI-EPILEPTIC ACTIVITY OF ETHANOLIC EXTRACT ON SWISS ALBINO MALE MICE

*Divyashree L. M. Pharm. and Nagalakshmi N. C.M. Pharm.

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Abstract

Objective: To study the antiepileptic activities,ethanolic extract of the leaves of Costus Igneus (EECI) in mice. Materials and Method: The antiepileptic activities of EECI was studied against maximal electroshock (MES) and chemical (Pentylenetetrazole and strychnine) induced seizure in mice. Result: The duration of tonic hind leg extension in MES model was significantly reduced by EECI at the dose of 100mg/kg and 200mg/kg. In PTZ model, oral administration of EECI at dose of 200mg/kg significantly delayed the onset of clonic convulsion and decrease the percentage of mortality. In strychnine mode EERA at the dose of 100mg/kg and 200mg/kg significantly delayed the onset of tonic extensior convulsion. Conclusion: The study revealed the protective action of the EECI against the various model of epilepsy in exprimental mice. This beneficial effect of Costus Igneus plant might be due to presence of antioxidant (β-carotene), Saponins, Flavonoids property and CNS depressent property.

Keywords: Epilepsy, Costus Igneus, Maximalelectroshock, Pentylenetetrazole, Strychnine seizure.