Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF MICROEMULSION USING NATURALLY PREPARED LEAF EXTRACT OF AEGLE MARMELOS(Bael) BY HIGH PRESSURE EMULSIFICATION METHOD

S. Harika*, B. Deepika, E. Chandrashekhar, M. Ramakrishna, Maskur Ahamed, Md. Rafi Shaik and D. Madhan

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Abstract

This study, aimed to develop a microemulsion formulation utilizing sesame oil, Aegle marmelos leaf extract and decyl glucoside surfactant and propylene glycol co-surfactant for potential applications in pharmaceutical and cosmetic industries. The microemulsion system was prepared using a spontaneous emulsification method. The pseudo – ternary phase diagram was constructed to determine the optimal composition of microemulsion, considering different ratios of sesame oil, Aegle marmelos leaf extract and decyl glucoside surfactant and propylene glycol co-surfactant. The results demonstrated that the microemulsion formulation composed of 10% sesame oil, 20% Aegle marmelos leaf extract and 70% decyl glucoside surfactant exhibited the smallest droplet size (less than 100nm) characterization of prepared microemulsion were done by stability studies, viscosity, pH, optical transmission, dye solubility test. Moreover, the optimized microemulsion exhibited enhanced solubility and encapsulation efficiency for the bioactive components present in Aegle marmelos leaf extract.

Keywords: Aegle marmelos, Decyl-glucoside, Pseudo-ternary phase diagram, Bio-active compounds, Sesame oil.