Abstract

INVITRO EVALUATION OF ANTI-NEURODEGENERATIVE ACTIVITY USING PSYCHOBIOTIC ISOLATES FROM PUNICA GRANATUM

Silpa O., Monica A. and Vanitha B.*

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Abstract

Neurodegenerative diseases are a broad category of neurological disorders that impact different groups of neurons in different functional anatomical systems. They develop for unexplained reasons and advance in an unrelenting manner. The two most prevalent neurological disorders are Alzheimer's and Parkinson's disease. Alzheimer's disease is a form of dementia that impairs memory, and behavior. Typically, symptoms appear gradually and worsen over time until they are severe enough to hinder regular activities. Parkinson’s disease is due to the brain's loss of nerves. In both of these disorders, two enzymes namely acetylcholinesterase and tyrosinase play a crucial role. In this case, we should inhibit the action of these enzymes. The research reveals that psycho-biotics could be a realistic alternative for maintaining mental health by inhibiting these enzymes. In this work, psycho-biotic metabolites of pomegranate fruit show positive results for anti-neurodegenerative activity.

Keywords: Neurodegenerative disorders, Alzheimer’s, Parkinson’s, cetylcholinesterase, Tyrosinase.