Abstract

FORMULATION AND EVALUATION OF PULCINCAP DRUG DELIVERY OF ELETRIPTAN HYDROBROMIDE

Dhanashri Pandurang Garud* and Priyanka Suresh Lohar

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Abstract

The current study aims to develop and evaluate a colon specific, pulsatile drug delivery system based on a cross-linked gelatin capsules. Pulsincap of Eletriptan Hydrobromide providing chronomodulated therapy for the better treatment of migraine. The paper demonstarte the study of compatibility between drug candidate with excipients using FTIR and conversion of soluble capsule shells into insoluble by treatment of formaldehyde and evaluate treated capsules. The present research concluded that the Eletriptan Hydrobromide was done and it was found that Eletriptan Hydrobromide shows melting point 170°C, and wavelength of 221 nm in Distilled water, characterization of FTIR peaks shows all functional group of Eletriptan Hydrobromide. FTIR data confirm that there was no chemical interaction of the drug with the other components used in the formulation Treatment of capsule with formaldehyde indicates that crosslinking of capsule occurs which results in decrease solubility of capsules so that capsules remain intact up to 14 hours by using 15% formaldehyde solution.

Keywords: Pulsatile drug delivery system, Migraine, Lag time, Triptans.