Abstract

PHYSICO-CHEMICAL STANDARDIZATION STUDIES OF AN IMPORTANT UNANI DRUG: ARQ-E-MUSSAFFI-E-KHOON

Asma Sattar Khan*, Shoeb Ahmed Ansari, Usha Devi, Suryansh Kashyap, Reesha Ahmed and Firoz Ahmad Ansari

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Abstract

Unani remedies are a significant healthcare alternative for sustaining good health, therefore standardizing their herbal formulas is crucial in light of the growing interest in ancient systems of medicine. To take advantage of worldwide potential, the validation of Unani formulation critically needs a systemic scientific process. Herbal formulations are typically created using conventional techniques in accordance with the steps outlined in classical literature, which occasionally lacks scientific support. To assure their legitimacy and medicinal effects, it is crucial to standardize the production process and phytochemical characteristics. Arq-e-Mussaffi-e-Khoon, a poly-herbal Unani formulation that is frequently used as "blood purifiers," has been standardized using a number of quality control parameters. This medication is regarded as safe for long-term therapy and is a highly effective blood purifier (Mussaffi-e-Dam) and antiseptic (Dafa-e-Ta'affun). Arq-e-Mussaffi-e-Khoon was made using the ingredients and procedures outlined in the National Formulacy of Unani Medicine (NFUM). The formulation was evaluated using standard analytical procedures, including organoleptic evaluation (color, taste, aroma and consistency) and physico-chemical evaluation (pH as such, weight per ml, Refractive index, optical rotation, volatile oil, and alcohol flavor assessment. In order to determine the quality of the medicine, evaluations of WHO parameters such heavy metals, aflatoxins, pesticide residues, and microbiological contaminations were also made in the formulation. The information gathered in this study will be used to create pharmacopeial standards that will ensure Arq-e-Mussffi-e-Khoon's quality and batch to batch consistency.

Keywords: Arq; heavy metal; Physico-chemical analysis; Pharmacopeial standard; WHO parameter.