Abstract

FORMULATION AND EVALUATION OF MUCOADHESIVE IN-SITU RECTAL GEL OF CLOTRIMAZOLE

*Sohel Khan, Shaikh Aaqueeb, S. K. Shehzad, Adnan Siddiqui, Dr. Rehan Deshmukh and Dr. G. J. Khan

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Abstract

The purpose of this study was to develop a suitable mucoadhesive in situ gel formulation of clotrimazole (CLO) for the treatment of rectal candidiasis. For the formulation of Clotrimazole, In-situ Mucoadhesive gel poloxamer-407 was used as thermo reversible agent and carbopol- 934 was used as mucoadhesive and pH sensitive agent. PEG 400 and 4000 was added to in situ gels in 0.5% ratio to improve the mucoadhesive and mechanical properties of formulations and to prolong the residence time in rectal cavity. After the preparation of mucoadhesive in situ gels; gelation temperature/time, viscosity, mechanical, mucoadhesive, syringeability, spreadibility and rheological properties and in vitro release determined. Based on the obtained results, it was found that gels prepared with PLX 407, Carbapol-934 and 0.5% PEG 400 and 4000 might be suitable for rectal administration of clotrimazole. In conclusion, the mucoadhesive in situ gels of clotrimazole would be alternative candidate for treatment of Rectal candidiasis since it has suitable gel properties with good rectal retention.

Keywords: Clotrimazole; HPMC; mucoadhesive in situ gel; poloxamer; rectal candidiasis.