Abstract

SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF CEFOPERAZONE SODIUM IN BULK AND PHARMACEUTICAL FORMULATIONS

K. Prabhavathi, N. Rami Reddy* and M. Mahammed Shafi

Abstract

A simple, sensitive, rapid and accurate colorimetric method has been developed for the estimation of cefoperazone sodium in bulk and pharmaceutical dosage forms. The proposed method was based on the formation of chloroform extractable complex of cefoperazone sodium with wool fast blue. The absorbance of the extractable ion pair complex is measured at the wavelength of maximum absorbance 585 nm against the reagent blank. The results obtained with the proposed method are in good agreement with labeled amounts, when marketed pharmaceutical preparations are analyzed. Results obtained are statistically validated and found to be reproducible.

Keywords: Spectrophotometry, Wool Fast Blue (WFB), cefoperazone sodium, Pharmaceutical formulation.