Abstract

SPANLASTICS: AN INNOVATIVE FORMULATION STRATEGY IN PHARMACEUTICAL DRUG DELIVERY

Afzal Khan, Chirag Varshney, Tushar Chaudhary, Balwan Singh* and K. Nagarajan

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Abstract

The Spanlastics are a new type of elastic vesicular nanocarrier that are based on surfactants and are composed of spans and edge activators. In 2011, a novel medication delivery method known as Spanlastics was released. This method had less adverse effects than previous methods and was part of an ongoing evolution in the drug delivery system. Spanlastics is a type of elastic nanovesicle that has the ability to carry a wide range of different drug molecules, which positions it as a candidate for use as a drug delivery carrier. The interest that Spanlastics have shown in various kinds of administrative strategies has been steadily growing. They are nanovesicles that are based on a surfactant and are elastic and malleable. Inside of them is completely enclosed an aqueous solute solution. It has been demonstrated that they are more chemically stable. They have improved various short comings of the standard dosage form, including providing targeting and controlled release of natural medicinal components, as well as other benefits. They solve a variety of issues that are associated with the conventional dosage form by delivering the active pharmaceutical components in a targeted manner and regulating the rate at which they are released. The purpose of this review is to provide an emphasis on the usefulness of spanlastics, the mechanism of penetration, their evaluation factors, the many preparation procedures and the applications.

Keywords: spanlastics, nanovesicles, edge activators, penetration and nanocarrier.