Abstract

GASTRORETENTIVE DRUG DELIVERY SYSTEMS: AN INNOVATIVE APPROACH TO ENHANCE ORAL DRUG BIOAVAILABILITY

Archana K. Gaikwad*, Kiran B. Mote, Yugashri Y. Kalam, Daivshala V. Chopade, Pratiksha P. Lahane

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Abstract

An Dosage forms with controlled release have been widely utilised to enhance treatment with a number of significant medications. Nevertheless, a number of physiological challenges face the development processes, including the incapacity to confine and localise the system inside the intended gastrointestinal tract region and the extremely variable nature of the gastric emptying process. In considering the possibility that this variability could result in erratic bioavailability and durations to reach peak plasma levels, gastroretentive drug delivery systems (GRDDS) have become a ground-breaking innovation in the pharmaceutical sciences. By extending the period that medications taken orally dwell in the stomach, these systems allow for more controlled release and improved bioavailability. This article thoroughly examines the several kinds of gastroretentive drug delivery systems, as well as their benefits, drawbacks, and uses in enhancing the therapeutic efficiency of different medications.

Keywords: GRDDS, Bioavilability, oral route, gastric residence.