Abstract

FORMULATION AND EVALUATION OF TIOCONAZOLE TRANSDERMAL PATCHES

Kiran Nag B. N.*, Nagendra R., Venkatesh and Hanumanthachar Joshi

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Abstract

The present research work is an attempt to formulate and evaluate Tioconazole Transdermal Patches for patient compliance by avoiding its gastrointestinal side effects. Tioconazole is an antifungal medication. It belongs to the Imidazole class. It is used to treat infections caused by a fungus or yeast. They are available in one-day doses, as opposed to the 7-day treatments commonly used in the past. Tioconazole is also used to treat ringworm, jock itch, athlete's foot, and tinea versicolor or sun fungus. Tioconazole taken orally undergoes a significant amount of metabolism. Glucuronide conjugates are the main metabolites. Erythema, stinging, blistering, peeling, edoema, prutitus, urticaria, burning and irritation of the skin, cramping, and urticaria are side effects of taking too much tioconazole. Tioconazole transdermal patches were prepared by solvent casting technique using various ratios of the polymers HPMC and PVP with the incorporation of PEG 400 as a plasticizer. Tioconazole transdermal patches were prepared using different ratios of HPMC and PVP polymers. Five formulations in total (TCZ1-TCZ5) were prepared. All the formulations were subjected to Physicochemical parameters such as Thickness, Uniformity of weight, tensile strength, folding endurance, percentage moisture absorption, percentage moisture loss and drug content. In vitro release studies of Tioconazole transdermal patches in phosphate buffer (pH, 7.4) were performed using a modified diffusion cell. Formulation TCZ3 containing HPMC and PVP in the ratio of 1:1 was found to be the most optimum formulation. TCZ3 was also found to exhibit a maximum in-vitro % drug release of about 92.54%. The patches were subjected to short term stability studies and were found stable.

Keywords: Tioconazole, Transdermal patches, drug delivery system, HPMC, PVP, Propylene Glycol.