Abstract

INSILICO MOLECULAR DOCKING AND DEVELOPMENT OF PIPER BETLE EXTRACT NANOEMULSION TO TREAT GOUT

*K.R. Prasanna, Anu Pandit, Dr. Sn Sri Harsha, Ayesha Siddiqa, Durgesh Bidye and Dr. Prabitha Prabhakaran

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Abstract

Gout is a pathological condition which is characterized by the uric acid in the form of monosodium Urate crystals get deposited in the joints, synovial fluid and other tissues and causes an inflammatory and painful condition called as gouty arthritis. The global gout incidence has increased by 63.44% over the past 2 decades. A computational ligand-target docking approach was used to analyze structural complexes of the target with bio active compounds (ligand) in order to understand the structural basis of this protein target specificity. Nanoemulsion was prepared by methanolic extract of piper betle leaves for efficient drug release for topical application in treatment of symptoms of Gout. The stable Nano-emulsion containing Piperol B, and quercitine and other constituents as active ingredient was successfully formulated the extract was prepared from leaves by soxhlation and used as active ingredient in Nano-emulsion. The activity of constituents toward the xanthine oxidase enzyme was determined by molecular docking.

Keywords: Gout, Nanoemulsion, Docking score, piper betle.