Abstract

THE ROLE OF PROBIOTICS IN NEUROPSYCHIATRIC DISORDERS

Ainampudi Yedukondalu*, Konchada Tavin Raju, Meka Prasanth Kumar, Yarasani Larence, Jabeer Shaik, Muhammad shahid, Dr. Apada Reddy Gangadasu, Dr. B. Thangabalan

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Abstract

Our review focused on the relationship between gut microbiota and neuropsychiatric diseases, highlighting the potential therapeutic effects of microbiota-targeted interventions. Recent studies, including a pilot randomized controlled trial on individuals with fibromyalgia, have demonstrated that administering a multispecies probiotic can improve attention, as shown by a significant decrease in errors of omission (p < 0.01). Additionally, probiotics enhanced bowel function compared to a placebo (p < 0.001). In patients with Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS), treatments aimed at correcting gut dysbiosis have been associated with improvements in symptoms and sleep quality, along with reduced cognitive reactivity to sad mood (p = .019). Research in neurodegenerative disorders such as Parkinson's and Alzheimer's suggests that manipulating the gut microbiota through dietary changes, medicinal herbs, and colon cleansing can alleviate symptoms, with Parkinson’s patients experiencing significant improvements in UPDRS III scores (p < 0.033). Furthermore, using Lactobacillus plantarum has been correlated with reduced depressive symptoms and better sleep quality, supported by improved sleep measures and cortical excitation (p < 0.05). These findings indicate a significant role of the gut-brain axis in neuropsychiatric health and suggest that microbiota-targeted therapies, including diet modifications, probiotics, and fecal microbiota transplantation, may effectively manage these conditions. However, further high-quality research is essential for translating these promising results into clinical practice.

Keywords: Microbiota, Probiotic, Neuropsychiatric, Psychiatric disorders, multiprobiotic strains.