Abstract

THIAMINE SUPPLEMENTATION IN DIABETES MELLITUS: A POTENTIAL THERAPEUTIC STRATEGY

Addeti Rohini Sastha*, Bodala Dharani, Puritipati Sai Mounika, Chinka Srinivas, Muchakayala Susmitha, Dr. Apada Reddy Gangadasu and Dr. B. Thangabalan

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Abstract

Thiamine, often known as vitamin B1, plays a crucial role in energy metabolism and the proper functioning of cells that rely on insulin. The presence of thiamine deficiency has been seen in individuals with diabetes mellitus, potentially leading to the worsening of comorbidities and metabolic abnormalities. A comprehensive examination was undertaken to evaluate the influence of thiamine levels on metabolic parameters in individuals diagnosed with diabetes based on current studies. This study investigated the correlation between plasma thiamine concentration, renal thiamine clearance, lipid profiles, glucose control, and diabetes complications. The findings of the review are as follows: Patients diagnosed with diabetes, including both Type 1 and Type 2, have a notable decrease in plasma thiamine concentrations when compared to individuals without diabetes. This decline cannot be attributed to inadequate food intake but rather to an elevated excretion of thiamine through the kidneys. Significant associations were seen between diminished thiamine concentrations and unfavorable lipid profiles, heightened glucose levels, and high blood creatinine levels. The possible mitigating effects of thiamine supplementation on these abnormalities have been demonstrated by a reduction in resting energy expenditure and enhancements in clinical indicators. In conclusion, it can be inferred that the available data indicates that adding thiamine supplementation may be a beneficial supplementary treatment in managing diabetes, as it can enhance metabolic results and decrease the likelihood of complications. Nevertheless, it is essential to do more studies to develop definitive protocols about the most effective dosage and long-term advantages of thiamine supplementation in individuals with diabetes.

Keywords: Thiamine, Diabetes Mellitus, Micronutrient Deficiency, Metabolic Regulation, Diabetic Complications, Thiamine Supplementation.