Abstract

INDOMETHACIN IN FOCUS: CHEMISTRY, PHARMACOKINETICS, AND ANALYTICS

Afzal Nagani*, Kripa Patel and Moksh Shah

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Abstract

This article provides a comprehensive exploration of Indomethacin, a non-steroidal anti-inflammatory drug, from a chemistry perspective. It covers the drug's history, structural composition, mechanism of action, pharmacokinetics, adverse effects, contraindications, molecular docking study, and various analytical methods used for its determination. Indomethacin's synthesis and chemical characteristics are highlighted, making it a valuable resource for researchers, chemists, and healthcare professionals seeking a detailed understanding of this important pharmaceutical compound. The provided information discusses various aspects of Indomethacin, a non-steroidal anti-inflammatory drug. It covers the history, chemical structure, mechanism of action, pharmacokinetics, adverse effects, contraindications, and medical uses of Indomethacin. Molecular docking gives an idea about the binding affinity of indomethacin towards various protein structures; and shows binding affinity ranging from -6.5 kcal/mol to - 9.6 kcal/mol, validation protocol, and method of docking also covered. Additionally, the article outlines numerous analytical methods for the determination of Indomethacin, including colorimetry, UV-Vis spectroscopy, fluorimetry, HPLC, LC-MS, and various electrochemical methods. The charts summarize the distribution of these analytical methods for Indomethacin determination.

Keywords: Molecular Docking, Indomethacin, UV-Vis spectroscopy, HPLC, LC-MS.