Abstract

ORALLY FAST DISINTEGRATING FILMS – A NOVEL DRUG DELIVERY SYSTEM

Sanika R. Toshniwal*, Prof. Aishwarya D. Ghuge and Dr. Swati P. Deshmukh

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Abstract

This review article present the oral disintegrating film as a novel approach. The orally disintegrating films are the novel drug delivery system in today’s scenario. It is the most popular and patient friendly method of medicines administration. This system is eminent of among pediatrics and geriatrics. Due to this simplicity, ability to prevent pain, this route is widely used. In this system the drug is swallowed which enters into the systematic circulation and gives desired effect. High stability, easy transportation, pleasant taste, ease of administration are some of it’s advantages. It’s formulation consideration involves active pharmaceutical ingredient, film forming polymers, plasticizers, surfactants, sweetening agents, saliva stimulating agents, flavoring agents and coloring agents. The method of preparation of orally disintegrating films involves the solvent casting method, semisolid casting, hot melt extrusion, solid dispersion extrusion and rolling method. The formulation is analyzed through various evaluation parameters. The orally disintegrating films are evaluated by thickness, dryness test, tensile strength, percent elongation, tear resistance, folding endurance, Young’s modulus, transparency, contact angle, in-vitro disintegration test, in-vitro dissolution studies, swelling property, content uniformity, percentage moisture loss, surface pH test, organoleptic test, permeation studies, stability study parameters. This review article also involves the packaging of orally disintegrating films. Thus, this review article emphasize on the novel approach of orally disintegrating films which helps in enhancing bioavailability, onset of action and thus produce a desired therapeutic effect.

Keywords: Solvent casting, hot melt extrusion, solid dispersion extrusion and compliance.