Abstract

ANTIDIABETIC AND ANTIDYSLIPIDEMIC ACTIVITIES OF COMBINED BANDOTAN (AGERATUM CONYZOIDES) AND SAMBUNG NYAWA (GYNURA PROCUMBENS) ETHANOL EXTRACTS IN INSULIN-RESISTANT RAT MODELS

Yani Mulyani*, Patonah Hasimun and Ella Fazila and Khairani Asfa

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Abstract

Unhealthy lifestyles are known to increase the risk of degenerative diseases, such as cardiovascular diseases, which greatly contribute to mortality worldwide. This condition often arises due to factors such as diabetes mellitus and dyslipidemi. Meanwhile, bandotan (Ageratum conyzoides) and sambung nyawa (Gynura procumbens) have been reported to possess antidiabetic and antidyslipidemic activities. Therefore, this study aimed to determine the antidiabetic and antidyslipidemic activities of bandotan and sambung nyawa ethanol extracts in insulin-resistant rat models. A pre and post-test control group design was used with 36 rats divided into six treatment groups. These included normal control (0.5% CMC), positive control (high-fat and fructose emulsion), metformin, simvastatin, as well as doses 1 (125:125) and 2 (250:250) mg/kgBW. In addition, the rats were induced into insulin resistance by administering a high-fat and fructose emulsion for 42 days, followed by 14 days of treatment. Blood glucose levels and lipid profiles were monitored at a specific time. The results showed that the combination dose of bandotan: sambung nyawa at 125 mg/kgBW: 125 mg/kgBW demonstrated significant potential for antidiabetic and antidyslipidemic activities.

Keywords: Antidiabetic, antidyslipidemic, bandotan, sambung nyawa, insulin resistance.