Abstract

SPRAY CONGEALING: A VERSATILE TECHNIQUE FOR PARTICLE PRODUCTION

Shraddha R. Lokhande*, Proff. Rani M. Deokar and Dr. Megha T. Salve

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Abstract

Spray congealing is also known as "spray cooling/ spray chilling". This method is used to obtain microparticles (MPs). The pharmaceutical industry continues to grapple with a significant concern, characterized by the inconsistent and often low oral bioavailability of poorly watersoluble drugs. Spray congealing is a technology for the production of solid dispersion to enhance the bioavailability of poorly soluble drugs by using low - melting hydrophilic excipients. Spray congealing is a simple technique, less time and energy consuming. It consists in a liquid atomization through a hot gas current to directly obtain a fine and dry powder. The aim of this review is to illustrate the potential of spray congealing in the preparation of microparticles aiming to enhance the oral bioavailability of poorly water-soluble drug. Spray congealing has been recently proposed as an emerging technology for the manufacturing of solid dispersion in the form of microparticles. Spray congealing is a dynamic and versatile process with applications spanning across various industries. This review article provides an in-depth exploration of the fundamentals, applications, advantages, challenges, and emerging trends in the field of spray congealing. Furthermore, an evaluation of the current state of industrial technology applications in the pharmaceutical sector is examined. The final part points out benefits, limitation and future perspective of this technology in drug delivery.

Keywords: microencapsulation, atomization, solubility enhancement, spray cooling, dissolution rate.