Abstract

A REVIEW ON NANOSPONGES-NOVEL APPROACH OF TARGETED DRUG DELIVERY

A. Selvi, R. Vigneswaran* and Dr. K. Sundaramoorthy

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Abstract

The aim of Novel Drug Delivery System is to provide a therapeutic amount of drug to the appropriate site in the body to accomplish promptly and then maintain the desired drug concentration. A number of novel drug delivery system has emerged encompassing various routes of administration, to achieve controlled and targeted drug delivery. Encapsulation of the drug in vesicular structure is one such system, which can be predicted to prolong the existence of the drug in systemic circulation and reduce the toxicity if selective uptake can be achieved. Consequently a number of vesicular drug delivery system such as liposomes, niosomes, transfersomes and pharmacosomes were developed. Nanosponge play vital role in targeting drugs delivery in a controlled manner. This sponge can circulate around the body until interact with specific target site and stick on surface and releasing drug in controlled manner both lipophilic and hydrophilic drugs are incorporated in nanosponge. Important characteristics of these sponges are their solubility in aqueous from and suitable for the drugs with poor solubility. This review is focusing on the preparation, advantages, characteristics and applications of nanosponges in the field of drug delivery.

Keywords: Nanosponges, synthesis, preparation, evaluation, ?-cyclodextrins, poor soluble drugs.