Abstract

SOLID DISPERSION: AN OVERVIEW

Rashmita A. Dalvi*, S. B. Gondkar, R. B. Saudagar

Abstract

Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of poorly water-soluble drugs. Solid dispersions of poorly water-soluble drugs with water-soluble carriers have been reduced the incidence of these problems and enhanced dissolution. The poor oral bioavailability as a result of poor aqueous solubility makes drug research and its development more difficult. Drug absorption, sufficient and reproducible bioavailability and/or pharmacokinetic profile in humans are recognized today as one of the major challenges in oral delivery of new chemical entities. New chemical entities (NCEs) often show poor water solubility necessitating solid dispersion formulation. Solid dispersions are one of the most promising strategies to improve the oral bioavailability of poorly aqueous soluble drugs by reducing drug particle size to the absolute minimum, increasing surface area and hence improving drug wettability, bioavailability may be significantly improved. Solid dispersion are obtained by two different methods i.e. melting and solvent evaporation usually presenting the amorphous product. To reduce the drawbacks of initial process new manufacturing processes have also been developed to obtain solid dispersions have also been developed. In this review, it is intended to discuss the recent advances in the area of solid dispersions.

Keywords: Solid dispersion, Improved bioavailability, Dissolution Enhancement.