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Abstract

AN EXTENSIVE REVIEW ON MUCOADHESIVE MICROSPHERES AS CARRIERS IN DRUG DELIVERY

M. Chandrasekar* and Dr. K. Sundaramoorthy

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Abstract

Among modified-release oral dosage form increasing interest has currently turned to systems designed to achieve prolonged retention at the site of drug delivery. The mucoadhesive microspheres offer better retention and controlled release. To overcome inherent drawbacks associated with conventional dosage forms, an attempt was made to develop an alternative drug delivery system in the form of mucoadhesive microspheres. The concept of mucosal adhesives, or mucoadhesives, was introduced into the controlled drug delivery arena in the early 1980s. Mucoadhesives are synthetic or natural polymers which interact with the mucus layer covering the mucosal epithelial surface and mucin molecules constituting a major part of the mucus. The concept of mucoadhesion has alerted many investigators to the possibility that mucoadhesive polymers can be used to overcome physiological barriers in long term drug delivery. The use of mucoadhesive polymers can solve a number of problems encountered in controlled drug delivery. They localize the formulation at a particular region of the body thereby improving bioavailability of drugs with low bioavailability. The increased contact time and localization of the drug due to the strong interaction between the polymer and mucus is essential for the modification of tissue permeability.

Keywords: mucoadhesive microspheres, polymers, bioavailability, controlled release.


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