Abstract

DEVELOPMENT, PREPARATION AND IN-VITRO CHARACTERIZATION OF MUCOADHESIVE BUCCAL TABLETS OF ETHAMSYLATE USING BIODEGRADABLE POLYMERS

Sudhir Priyadarshi* and Shaffi Khurana Tangri

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Abstract

The buccal route has various advantages, including greater compliance to patient, avoiding GIT, and preventing the hepatic First pass action. The goals are to develop a mucoadhesive buccal tablet containing Ethamsylate and appropriate excipients, and then to assess the goods through stand ard methodologies. As well as in vitro experiments. The substances were tested for compatibility using Fourier Transform Infrared Spectroscopy, and the results revealed no interaction. Ethamsylate buccal tablet was made in Five Formulations among which Formulation F4 found to be most Stable and Effective. The thickness and diameter of the tablets are 5.83mm to 6.93mm and 12.03mm to 12.11mm, respectively. All tablets are within +/- 5% of the standard. The hardness of tablets ranges from 6.5kg to 8.5kg, with a maximum friabilation of 0.75%. All tablets decomposed within 4 hours, according to the disintegration test. The content homogeneity of tablets was found to be between 85% and 115%. The weight of the tablet is within the ±5% range. The tablet's surface pH is near to salivary pH, This means it will not cause discomfort to the buccal mucosa. The pH remained unchanged also the size after being exposed to stability experiments in human saliva. Drug release trials after 8 hours found a range of 68.17% to 80.83%. The results are still within acceptable limits after three months of being subjected to 40°C and 75% RH. According to the findings, the formulation has the potential to be a mucoadhesive buccal tablet and also This research can help to build up patient compliance to uncooperative or unconscious Patient.

Keywords: Ethamsylate, Buccal Tablets, Mucoadhesion, SCMC, HPMC K4M.