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WJPR

World Journal of Pharmaceutical Research

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An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

SYNTHESIS DOCKING AND QSAR STUDIES OF QUINOLINE DERIVATIVES

B. Mayuri, N.Pramod*, R. Nagendra Babu, S.Chandra Prakash, R.J. Naveen Kumar, K. Madhuri

Abstract

Five novel quinoline derivatives (BPM-1 to BPM-5) are synthesized.The synthetic scheme of quinolines derivative involves the reactionbetween 2-methoxy acetanilide with Vilsmayer Hack reagent (POCl3,DMF).The formed 2-chloro-3-formyl-8-methoxy-quinolines. Furthertreated with sodium sulfide flakes resulted in to 3-formyl-8-methoxy 2-thio quinolines. Finally fused with various aryl amines to give 5-novelquinoline derivatives. Docking and Qsar studies where performed fordesigned compounds using Autodock 4.2 version. The results ofDocking and Qsar studies reveled that both compounds BPM-1 andBPM-2 possess similar antibacterial activity.

Keywords: Quinoline derivatives, Docking, QSAR, antibacterial activities.

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