Abstract

MICROSPHERES: AN OVERVIEW ON, METHODS OF PREPARATION, CHARACTERIZATION AND PHARMACEUTICAL APPLICATIONS

S. Indira, S. Dalston Ans, M. D. Amuthan, V. Gowsik and V. Mahalekshmi*

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Abstract

The pharmaceutical industry has demonstrated a strong interest in microparticulate drug delivery technologies. They enable the decrease of adverse effects and an improvement in the therapeutic efficiency of drugs. Microspheres are one of these carrier devices that have been studied extensively as they allow for both delivery of the drugs to a particular therapeutic target and control over it. The unstable drugs which include enzymes, proteins, and peptides are temporarily shielded by the microspheres for the effective delivery. Numerous drugs, including nucleic acids and small compounds, can be encapsulated in microspheres. The drug can be delivered to the target site with precision, even if modified, and the desired concentration can be maintained by this reliable method. Microspheres have drawn a lot of interest for their capacity to target cancer cells in addition to their sustained release. Combining with other approaches, it finds its main use in novel drug delivery, specifically in the areas of miserable cell sorting, diagnostics, and also in gene and genetic materials.

Keywords: Microspheres, Controlled drug delivery, Biodegradable polymer, Therapeutic Efficacy, Targeted drug delivery.