Abstract

A REVIEW ON CLOTRIMAZOLE LOADED TRANSETHOSOMAL GEL FOR CANDIDIASIS

S. Mohana*, V. Manimegalai and K. Sundaramoorthy

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Abstract

Candidiasis is one of the most common fungal infections. For the treatment, antifungal therapy is used. Clotrimazole is a topical broad spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis. Various disadvantages occur when the drug is administered as conventional form. In this dealing with the latest form of vesicular system like transethosomes. Transethosomes are one of the potential innovative nano-carriers for improving the solubility and permeation of poorly soluble and permeable drugs. When the drug is incorporated in the form of transethosomes which nullify the all the disadvantages when it is formulated in any other conventional systems and there by provide stable and more effective formulation, and also having high patient compliance. Transethosome containing high concentration of ethanol along with edge activator which provide high penetration to the skin and leads to better therapeutic action. Clotrimazole loaded transethosomes to overcome the skin barrier function. Clotrimazole loaded transethosomes fabricated by the cold method and followed by their incorporation into Carbopol 940 as a gel. The prepared clotrimazole loaded transethosomes were evaluated for percentage yield, Entrapment efficiency (EE), surface morphology, particle size, zeta potential. The development of transethosomal formulation can serve as an efficient drug delivery system through a topical route with enhanced efficacy and better patient compliance.

Keywords: Fungal infection, Clotrimazole, Transethosomes, Candidiasis, Edge activator.