Abstract

DERMATOFIBROSARCOMA PROTUBERANS - CASE STUDY

*Dr. Menka Changle and Dr. Dhanraj Gaikwad

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Abstract

Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue tumor that involves the dermis, subcutaneous fat, and in rare cases, muscle and fascia. The tumor typically presents as a slowly growing, firm plaque mainly on the trunk of young adults. The cause of DFSP is not clearly understood. Studies have implicated a chromosomal translocation, resulting in the fusion protein COL1A1-PDGFB, which promotes tumor growth through the overproduction of platelet-derived growth factor (PDGF). Diagnosis is made via skin biopsy. DFSP is considered an intermediate-grade malignancy with a low likelihood of metastasis but a high local recurrence rate. Given its propensity for a subclinical extension, the optimal treatment modality for DFSP is Mohs micrographic surgery (MMS), a surgical technique that allows complete margin assessment and tissue preservation. Alternatively, DFSP can be treated with wide local excision, chemotherapy or radiation therapy.

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