Abstract

FORMULATION AND EVALUATION OF SELENIUM NANOPARTICLES OF ALBENDAZOLE FOR ORAL DELIVERY

Harsha Kahar* and Archana Bagre

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Abstract

Selenium is an essential micronutrient required for proper functioning of biological and metabolic mechanism within the human body. Deficiency of selenium leads to the generation of several harmful disorders such as cancer, neurological, muscular, immune, etc. Albendazole is widely used to treat a variety of infections due to its high efficacy compared with others drugs; however, their side effects must be considered. The objective of the present study was to formulate and evaluate Selenium nanoparticles of Albendazole for oral delivery. SeNPs were synthesized by mixing the Albendazole drug with a salt stock solution. From all the formulations, formulation 4 was considered as the optimized formulation with 149.1 nm of particle size and -3.9mV zeta potential. The spectrum of UV–visible of the Albendazole shows an absorption peak at 291 nm due to the excitation of surface plasmon resonance (SPR). SEM image showed SeNPs have a spherical shape. The drug release data of selected batch were fitted into different kinetic models which show that the drug release from SeNPs follows Highuchi kinetic model. From the current research work it was concluded that the Albendazole loaded SeNPs consisting of better drug release and good stability.

Keywords: Selenium, Albendazole, SeNPs, Highuchi kinetic model, Disorders.