Abstract

CURCUMIN FROM TURMERIC (CURCUMA LONGA): A COMPREHENSIVE REVIEW OF ITS PHARMACOLOGICAL PROPERTIES AND CLINICAL APPLICATIONS

Sneha Pandey, Shubhankit Soni*, Dr. Alok Shukla and Nitin Rajan

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Abstract

Curcumin, the bioactive compound derived from the turmeric plant (Curcuma longa), has gained considerable attention for its diverse pharmacological properties and potential clinical applications. This comprehensive review synthesizes current knowledge on curcumin, encompassing its chemical composition, pharmacokinetics, and pharmacodynamics. The biological activities of curcumin, including its anti-inflammatory, antioxidant, anti-cancer, and neuroprotective effects, are explored through an analysis of experimental evidence from in vitro and in vivo studies. The review delves into clinical applications, summarizing findings from trials investigating curcumin's therapeutic potential across various medical conditions. Mechanisms of action at the molecular level, as well as challenges related to bioavailability and formulation, are discussed. Safety considerations, dosage recommendations, and the integration of curcumin with conventional medicine are also examined. The review concludes by addressing current challenges in curcumin research and proposing future directions for advancing its clinical applications.

Keywords: Curcumin, Turmeric, Curcuma longa, Pharmacological properties, Clinical applications, Biological activities, Anti-inflammatory, Antioxidant, Anti-cancer, Neuroprotective, Pharmacokinetics, Pharmacodynamics, Experimental evidence, Clinical trials, Mechanis