Abstract

A REVIEW ON NITROGEN CONTAINING ANTICANCER AGENT, AS A BREAKTHROUGH MEDICINAL CHEMISTRY PERSPECTIVE

Aniruddha Dattatray Sonje*, Rahul B. Lovhare, Hitendra S. Chaudhari and Dr. S. P. Pawar

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Abstract

Cancer is one of the leading causes of death worldwide. Mutation of the cell regulates genes and protein causing cancer. Surgery, radiotherapy, and the use of anticancer agents are the current therapy of cancer despite their side effects. The general area of research relates to heterocyclic chemistry. The purpose of the article is to review the most recent advances in nitrogen -containing heterocyclic as possible chemotherapy agents for cancer. More than 80% of the novel drugs bear heterocyclics and among them, nitrogen-containing heterocyclic compounds show superior pharmaceutical effect than non- nitrogen compounds. Nitrogen-containing compounds, the heart of drug discovery, present a significant and valuable group of molecules that play a chief and vital role in the metabolism of living cells. More than 85% of all physiologically active pharmaceuticals are heterocycles or contain at least one heteroatom. In this study, we have compiled the FDA approved heterocyclic drugs with nitrogen atoms and their pharmacological properties. Moreover, we have reported nitrogen containing heterocycles, including pyrimidine, quinolone, carbazole, pyridine, imidazole, benzimidazole, triazole, ß-lactam, indole, pyrazole, quinazoline, quinoxaline, isatin, pyrrolobenzodiazepines, and pyrido[2,3-d]pyrimidines, which are used in the treatment of different types of cancer, concurrently covering the biochemical mechanisms of action and cellular targets.

Keywords: Heterocyclic; anti-cancer; FDA: nitrogen-containing heterocyclic; biological activity.