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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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World Journal of Pharmaceutical Research (WJPR) is giving Best Article Award in every Issue for Best Article and Issue Certificate of Appreciation to the Authors to promote research activity of scholar.

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Abstract

METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF IVACAFTOR AND TEZACAFTOR BY RP-HPLC

*Manikanta Kumar Y. S. S.

Abstract

A novel RP-HPLC technique was developed for simultaneous quantification of Tezacaftor and Ivacaftor drugs which is used to cure cystic fibrosis. The method was developed using Inertial -ODS C18 (250 x 4.6 mm, 5) column, flow rate was 1.0 ml/min, mobile phase ratio was Methanol: Buffer (45:55), and detection wavelength was 254 nm. The chromatographic conditions for the separation of Tezacaftor and Ivacaftor were effectively created.

Keywords: Tezacaftor, Ivacaftor, RP-HPLC, Method Development, Validation.

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