Abstract

FAST DISSOLVING TABLETS: BRIDGING GAP IN PATIENT COMPLIANCE - A REVIEW

Pasupuleti Divya* and Yadla Bhuvana Lakshmi

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Abstract

Fast-dissolving tablets have become widely accepted and popular, especially among older patients with Parkinson's illness or tremors in hand and juvenile patients with underdeveloped muscles and neurological systems.[1] In contemporary times, certain forms of solid dosage, such as capsules and tablet forms, are confronted with challenges like trouble swallowing, which makes it difficult for the patients to follow their prescribed course of action and reduces the effectiveness of the treatment. Although oral dose and oral administration continue to be the most effective ways to take different medications, they have drawbacks, including the first-pass metabolism and limited application to patients with mental illness, immobile patients, and uncooperative patients. Fast-dissolving tablets can disintegrate or break down quickly in saliva without Water. They prepare them for rapid dissolution, often achieving this within a few seconds (usually less than 60 seconds), which earns them the title of proper FDTs. Super disintegrating agents enhance the tablet's breakdown in the buccal cavity. These tablets provide a viable alternative for older and younger patients because of their portability, ease of manufacture, accurate dosing, and robust physical and chemical stability. Fast-dissolving tablets disintegrate rapidly, leading to faster absorption and an improvement in vitro drug release time, ultimately enhancing the bioavailability of drugs in this dosage form.[2] FDT formulations combine the advantage of liquid dosage and traditional tablet formulations. Researchers and pharmaceutical companies have developed numerous conventional and patented technologies for manufacturing fast-dissolving tablets, including spray drying, sublimation, direct compression, and freeze-drying (lyophilization). This Article briefly introduces fast-dissolving tablets, including their purpose, benefits and the criteria they meet. It also highlights some prominent features, limitations, and challenges in their development and an overview of many formulations of FDTs now available in the market.

Keywords: Fast dissolving tablets (FDTs), Super disintegrants, drug delivery system, patented technologies, taste masking.