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Abstract

AN EFFECTIVE NOVEL RED BRICK POWDER CATALYSED SYNTHESIS, IN-SILICO AND IN-VITRO ANTI-INFLAMMATORY STUDIES OF IMIDAZOL-5-ONE DERIVATIVES

Bhargav A.*, Yashwanth R., Smitha Jose and Pavan Kumar C.

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Abstract

In-silico studies for targets were carried out using PyRx and various softwares. The compounds with highest binding affinities were selected for synthesis and biological evaluation. Oxazolin-5-ones were prepared by condensation of hippuric acid and various substituted benzaldehydes. Imidazole-5-ones were synthesized by the reaction between various oxazolin-5-ones with substituted anilines, sulfanilamide, sulfamethoxazole, and 4-amino antipyrine in the presence of red brick powder as a green catalyst. In-vitro antiinflammatory activity was performed by modified protein denaturation (Bovine serum albumin) assay method for the compounds. Compounds SW-7 and SW-8 showed significant activity when compared with standard diclofenac sodium.

Keywords: Oxazolin-5-one, Imidazol-5-one, Green catalyst, Red Brick powder, anti-inflammatory.


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