Abstract

EVALUATION OF IN-VITRO ANTIOXIDANT AND HYPOGLYCEMIC POTENTIAL OF FLAVONOIDS FRACTION OF PTERIDIUM AQUILINIUM LEAF

Chizoba Ojimelukwe, Obinna Ajah, Cecilia Chika Unegbu and Ikenna Elvis

Abstract

Many of the world population has insight in the use of plants and herbs in their environs for treatment and management of different diseases. Herbal medicines are often used to provide first line and basic health services, both in people living in remote areas where it is the only available health service and to people living in poor areas where it offers the only affordable remedy. This present study evaluated the potential effect of extracted flavonoids fractions of Pteridium aquilinium leaf as antioxidant and hypoglycemic agent. The antioxidant activity was done using standard methods (inhibition of nitric oxide assay, inhibition of hydrogen peroxide, inhibition of lipid peroxidation, and reducing power assay) and the in vitro hypoglycemic activity was done using Alpha-Glucosidase Inhibitory activities assay, Lipase activity assay, and Glucose absorption Capacity assay. The result of the percentage alpha glucosidase inhibition ranged from 52.18 to 68.67%. The flavonoids fraction of Pteridium aquilinium showed significant (p

Keywords: Diabetes, oxidative stress, hypoglycemic agent, antioxidant, Pteridium aquilinium.