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Abstract

FLOATING IN SITU GEL: AN APPROACH FOR IMPROVED BIOAVAILABILITY

Akshay Gangadharmath*, E. Gopinath, Ganesh N. S., J. Adlin Jino Nesalin and Vineeth Chandy

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Abstract

The development of in situ gelling systems that are gastro retentive has sparked renewed interest in academia and industry. This is because the in situ gelling system has many benefits, such as ease of administration and lower administration frequency, which promote patient compliance. A method called gastric retentive drug delivery can achieve site-specific drug release in the upper gastrointestinal tract for either a local or systemic effect by prolonging the gastric residence period. When floating drug delivery devices come into contact with stomach fluid, they float quickly. They have a low bulk density (1.00 g/cm3) and are buoyant enough to float above stomach fluid for a lengthy period of time while the medicine releases at the desired pace at a particular location. Such gel transformations are caused by one or more mechanisms, including physiological stimuli (for example, temperature and pH), physical changes in biomaterials (for example, solvent transport and swelling), and chemical reactions (for example, enzymatic, ionic, and photo initiated polymerization). In situ gelling systems can be formulated via different routes such as oral, nasal, ophthalmic, etc. Various natural and synthetic polymers such as gellan gum, alginic acid, xyloglucan, pectin, chitosan, poly (DL lactic acid), poly (DLlactide-coglycolide), and poly-caprolactone are used for formulation development of in situ forming drug delivery systems. Traditional oral dosage forms exhibit low bioavailability as a result of the stomach’s quick emptying. The goal of this study is to conduct a review on a novel in-situ gel. The gastroretentive in situ gelling system helps to increase the bioavailability of the drug compared to conventional liquid dosage forms.

Keywords: Gastroretentive in situ gel, floating drug delivery system, Gastroretentive in situ gelling system.


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