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Abstract

A STUDY ON DRUG UTILIZATION EVALUATION OF NON STEROIDAL ANTI INFLAMMATORY DRUGS IN A TERTIARY CARE HOSPITAL

Krupa Sandhya*, Kavadi Deepak, P. Eeshitha, Mohammed Sumaya, B. Jeevana

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Abstract

The present study was aimed to evaluate the utilization of NSAIDs in a Tertiary Care Hospital. The secondary objectives are to assess coprescription with gastro protective agents, the nature and severity of adverse drug reactions and Drug-Drug interactions, with an intention to prevent the inappropriate use of NSAIDs. A prospective study was carried out in 300 in-patients of various departments of the hospital during the 6 months period of Aug 2023 to Jan 2024. Out of 300 patients, 103 were Male and 197 were Females, in which most of the patients (84) were belonging to age group of 0-10years. The major complaint of the patient was pyrexia (42.39%). Most of the patients were prescribed with single NSAIDs as monotherapy, although some patients were prescribed with combinations of NSAIDs such as Ibuprofen+paracetamol, Paracetamol+mefenamic acid, Aceclofenac + Paracetamol, Pcm+diclofenac+ibuprofen, Paracetamol+aspirin, Paracetamol+dicyclomine. Most of the patients (78.3%) were prescribed with non selective COX inhibitors and few patients (11.0%) were prescribed with preferential COX2 inhibitors and remaining were prescribed with combination of Non Selective Cox Inhibitors And Preferential Cox 2 Inhibitors. Selective COX 2 inhibitors were not prescribed. Paracetamol (60.33%) and Diclofenac (9%) were mostly prescribed and least prescribed NSAIDs were Aceclofenac and Ibuprofen. Most of the NSAIDs were prescribed via oral route (74.6%), parentral route (8.2%) and combinations of route of administrations (16.6%). The suppository NSAIDs (0.3%) and topical + suppository NSAIDs (0.3%) were least prescribed. Drugs can be useful tools in the prevention and management of symptoms and disease, but if not used properly, they may be harmful and cause new symptoms or produce suboptimal effects.

Keywords: Non steroidal anti inflammatory drugs, Hospitalized patients, prescription, drug-drug interactions, prevention and management.


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